AN ANALYTICAL MODEL FOR PREDICTION OF CONTROLLED RELEASE FROM BULK BIODEGRADING POLYMER MICROSPHERES

Farzane Sivandzade

doi:10.22159/ajpcr.2018.v11i3.23219

Authors

Farzane Sivandzade Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran.

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i3.23219

Keywords:

Analytical method, Biodegrading polymer, Microsphere, Controlled release, Model

Abstract

Â Objective: A convenient numerical model has been developed to predict release profile of different types of agents from bulk biodegrading polymer microspheres, including magnitude methods are less accurate than analytical methods. Usually, this study used analytical solutions for the model and compared the analytical results with numerical solution and experimental data.

Methods: The objective drug controlled release profiles were modeled based on a four-phase pattern. Then, a specific formulation was considered based on Fick's second law. After calculating various parameters, the equations were solved using an analytical method.

Results: Comparison results showed that analytical solution can reproduce experimental behavior of controlled release systems with a higher accuracy.

Conclusion: Although in previous work, drug release profile from a polymer matrix composed of poly lactic-co-glycolic acid was predicted using readily attainable parameters and representing tunable matrix properties by a numerical method, the proposed analytical method can give more accurate results compared to the numerical method.

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References

Arafat M. Approaches to achieve an oral controlled release drug delivery system using polymers: A recent review. Int J Pharm Pharm Sci 2015;7:16-21.

Freiberg S, Zhu XX. Polymer microspheres for controlled drug release. Int J Pharm 2004;282:1-8.

Jain RA. The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 2000;21:2475-90.

Jiang W, Gupta RK, Deshpande MC, Schwendeman SP. Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens. Adv Drug Deliv Rev 2005;57:391-410.

Rothstein SN, Federspiel WJ, Little SR. A unified mathematical model for the prediction of controlled release from surface and bulk eroding polymer matrices. Biomaterials 2009;30:1657-64.

Rothstein SN, Federspiel WJ, Little SR. A simple model framework for the prediction of controlled release from bulk eroding polymer matrices. J Mater Chem 2008;18:1873-80.

Siepmann J, GÃ¶pferich A. Mathematical modeling of bioerodible, polymeric drug delivery systems. Adv Drug Deliv Rev 2001;48:229-47.

Arifin DY, Lee LY, Wang CH. Mathematical modeling and simulation of drug release from microspheres: Implications to drug delivery systems. Adv Drug Deliv Rev 2006;58:1274-325.

Siepmann J, Faisant N, Benoit JP. A new mathematical model quantifying drug release from bioerodible microparticles using monte carlo simulations. Pharm Res 2002;19:1885-93.

Raman C, Berkland C, Kim KK, Pack DW. Modeling small-molecule release from PLG microspheres: Effects of polymer degradation and nonuniform drug distribution. J Controll Release 2005;103:149-58.

Thombre A, Himmelstein K. A simultaneous transport-reaction model for controlled drug delivery from catalyzed bioerodible polymer matrices. AIChE J 1985;31:759-66.

Saltzman WM, Langer R. Transport rates of proteins in porous materials with known microgeometry. Biophys J 1989;55:163-71.

GÃ¶pferich A, Langer R. Modeling of polymer erosion in three dimensions: Rotationally symmetric devices. AIChE J 1995;41:2292-9.

Batycky RP, Hanes J, Langer R, Edwards DA. A theoretical model of erosion and macromolecular drug release from biodegrading microspheres. J Pharm Sci 1997;86:1464-77.

Ravichandran V, Shalini S, Sundram K, Harish R. Validation of analytical methodsâ€“strategies and importance. Int J Pharm Pharm Sci 2010;2:18-22.

Von Burkersroda F, Schedl L, GÃ¶pferich A. Why degradable polymers undergo surface erosion or bulk erosion. Biomaterials 2002;23:4221-31.

Siepmann J, Elkharraz K, Siepmann F, Klose D. How autocatalysis accelerates drug release from PLGA-based microparticles: A quantitative treatment. Biomacromolecules 2005;6:2312-9.

Fredenberg S, Reslow M, Axelsson A. Measurement of protein diffusion through poly(D,L-lactide-co-glycolide). Pharm Dev Technol 2005;10:299-307.

Panyam J, Dali MM, Sahoo SK, Ma W, Chakravarthi SS, Amidon GL, et al. Polymer degradation and in vitro release of a model protein from poly (D, L-lactide-co-glycolide) nano-and microparticles. J Controll Release 2003;92:173-87.

GÃ¶pferich A, TeÃŸmar J. Polyanhydride degradation and erosion. Adv Drug Delivery Rev 2002;54:911-31.

Grayson AC, Voskerician G, Lynn A, Anderson JM, Cima MJ, Langer R, et al. Differential degradation rates in vivo and in vitro of biocompatible poly(lactic acid) and poly(glycolic acid) homo- and co-polymers for a polymeric drug-delivery microchip. J Biomater Sci Polym Ed 2004;15:1281-304.

Crank J. The Mathematics of Diffusion. 2nd ed. United states: Clarendon Press; 1975.